AIM:

 

High levels of fatty acid synthase have shown to correlate with the aggressiveness of prostate cancer. As [11 C]acetate exhibits a close correlation with the level of fatty acid synthase, we aimed to assess whether the SUV in [11 C]acetate PET serves as a suitable prognostic marker in patients with recurrent prostate cancer.

 

MATERIALS AND METHODS:

 

In 123 consecutive patients, examined between 2010 and 2014, the maximum standardized uptake value (SUVmax) of local recurrences as well as lymph node and bone metastases was measured. Choosing the spleen as a standard for relatively high physiological uptake, a ratio of tumor to spleen uptake (SUVts) was calculated for standardizing the uptake, too. The corresponding initial Gleason scores (GS) and serum-PSA levels around the time of the performed PET/CT for each patient were retrospectively collected and PSA doubling together with PSA velocity were determined. For further analysis patients were divided with regard to their initial Gleason score (≤3 + 4 and ≥ 4 + 3). The median of PSA velocity was calculated to separate patients with a high and low PSA velocity and Mann-Whitney U or Student's t-test were used, testing for significant differences. For correlation Spearmen-Rho test was used.

 

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