This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin. Blood samples were analysed using a validated liquid chromatography tandem mass spectrometry technique. A population pharmacokinetic analysis was performed using non-linear mixed effects modeling. Five hundred and fifteen blood samples were collected over one to six dosing intervals from 12 patients. The mean (SD) age was 62 (17) years, 67% were male and creatinine clearance (CLCR) ranged from 30 to 300 mL/min.

 

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