Acteoside is a representative phenylethanoid glycoside, exhibiting great potency in neurodegenerative diseases treatment, such as Alzheimer's disease. This study was aimed to explore the pharmacokinetic characteristics, tissue distribution, excretion and plasma protein binding of acteoside in Sprague-Dawley rats after oral administration at 20, 40 and 80 mg/kg by a validated LC-MS/MS method. Acteoside was absorbed quickly after oral administration at 3 dose levels. Acteoside reached the peak concentration at 0.29±0.17 h, exhibiting a maximum concentration (Cmax) of 312.54±44.43 ng/mL after oral administration at 40 mg/kg, and the elimination half-life was 1.05±0.23 h. Both the Cmax and AUC showed a linear increase with the oral doses administered.

 

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