Only specific base pairs on DNA can bind with each other through hydrogen bonds, which is called Watson/Crick (W/C) pairing rule. However, without the constraint of DNA chains, the nucleobases in bulk aqueous solution usually do not follow the W/C pairing rule anymore because of strong competitive effect of water and multi-interaction edges of nucleobases. The present work applied surfactant aggregates non-covalently functionalized by nucleotide to enhance the recognition between nucleobases without DNA chains in aqueous solution and revealed the effects of their self-assembling ability and morphologies on the recognition. Cationic ammonium monomeric, dimeric and trimeric surfactants DTAB, 12-3-12, and 12-3-12-3-12 were chosen.

 

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