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| Safety and pharmacokinetics of bapineuzumab in a single ascending-dose study in Japanese patients with mild to moderate Alzheimer's disease. | |||
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| 분류 | Pharmacokinetics | 조회 | 1545 |
| 발행년도 | 2015 | 등록일 | 2015-10-09 |
| 출처 | Geriatr Gerontol Int (바로가기) | ||
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AIM:
To evaluate the safety, tolerability and pharmacokinetic profile of bapineuzumab after a single intravenous injection in Japanese patients with mild to moderate Alzheimer's disease.
METHODS:
Participants received either a placebo (n = 8), or bapineuzumab 0.15 (n = 6), 0.5 (n = 6), 1.0 (n = 6) or 2.0 (n = 6) mg/kg. Serum concentrations of bapineuzumab, antibapineuzumab antibody and total plasma β-amyloidx-40 were assayed.
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