Different formulation strategies have been proposed for poorly water-soluble drugs. The objective of this study is to give an in vitro and in vivo comparison of a solid dispersion, micronization, and nanocrystals, with lacidipine as a model substance. Micronized lacidipine was obtained by jet milling, and nanocrystals were prepared by bead milling. The d50 for the microcrystals (11,200nm) was about 20 times larger than that for nanocrystals (623nm). Both colloidal dispersions maintained a crystalline state after milling. Lacipil®, lacidipine solid dispersion, was purchased from GlaxoSmithKline.

 

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