Pharmacokinetics and skin-tissue penetration of daptomycin in rats | |||
---|---|---|---|
분류 | Pharmacokinetics | 조회 | 1523 |
발행년도 | 2015 | 등록일 | 2015-10-08 |
출처 | Matsumoto K 외 10명 (바로가기) | ||
BACKGROUND:
Daptomycin is recommended for complicated skin and skin-structure infections. However, information on the penetration of daptomycin into skin is limited. Therefore, the aim of this in vivo investigation was to determine the pharmacokinetics and skin penetration of daptomycin in rats.
MATERIALS AND METHODS:
Concentrations of daptomycin were determined by high-performance liquid chromatography. A noncompartmental pharmacokinetic analysis was conducted to estimate the rate and extent of daptomycin penetration from the systemic circulation into skin tissue. Since protein binding of daptomycin in rat serum was 89.3%, the free maximum concentration (Cmax) and free area under the curve from time 0 to infinity (AUC0-∞) for plasma were calculated as follows: fCmax, plasma = (1 - 0.893) × Cmax, plasma, fAUC0-∞, plasma = (1 - 0.893) × AUC0-∞, plasma.
(후략)
|
|