IMPORTANCE:

Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non-AD dementia.

OBJECTIVE:

To use individual participant data meta-analysis to estimate the prevalence of amyloid positivity on PET in a wide variety of dementia syndromes.

DATA SOURCES:

The MEDLINE and Web of Science databases were searched from January 2004 to April 2015 for amyloid PET studies.

 

(후략)