BACKGROUND:

Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, along with absorption, distribution, metabolism, and excretion (ADME) properties of chemicals.

OBJECTIVES:

A conceptual workflow was developed to consider exposure and ADME properties in relation to an MIE. The utility of this workflow was demonstrated using a previously established AOP, acetylcholinesterase (AChE) inhibition.

 

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