Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors. | |||
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분류 | ADME | 조회 | 1326 |
발행년도 | 2015 | 등록일 | 2015-09-26 |
출처 | Bioorg Med Chem (바로가기) | ||
In order to probe the S1 and S1' mammalian aminopeptidase N subsites, racemic 1- or 4-substituted 7-aminobenzocyclohepten-6-one derivatives were synthesized and evaluated for their ability to inhibit mammalian aminopeptidase N.
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이전글 | Discovery of a novel Kv7 channel opener as a treatment for epilepsy. |
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다음글 | Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects. |