The aim of this study was to investigate the brain targeting potential of chitosan-coated oil in water nanoemulsions (CSNEROP) delivered intranasally in haloperidol-induced Parkinson's disease rat models. Chitosan-coated nanoemulsion (CSNEROP) was developed through aqueous titration followed by a high pressure homogenization method. Gamma-scintigraphy study showed a significantly high mucoadhesive potential of CSNEROP and least for conventional and homogenized formulations in. Confocal study showed deep localization of formulations in the brain confirming the permeation potential of CSNEROP. Pharmacokinetic results of CSNEROP in Wistar rat brain and plasma showed a significantly high (p* < 0.005) AUC0→24 and amplified Cmax over i.v treatment group.

 

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