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| We characterized the pharmacokinetics of enzalutamide, a novel anti-prostate cancer drug, in rats after intravenous and oral administration in the dose range 0.5-5 mg/kg. Tissue distribution, liver microsomal stability, and plasma protein binding were als | |||
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| 분류 | pharmacokinetics | 조회 | 1355 |
| 발행년도 | 2015 | 등록일 | 2015-09-24 |
| 출처 | Eur J Drug Metab Pharmacokinet (바로가기) | ||
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Honokiol (HK) is the main bioactive compound isolated from the bark of Magnolia officinalis. The present work is the first to report the pharmacokinetics and distribution of HK and its two metabolites of hydroxylated HK conjugated with glucuronic and sulfuric acid (M1) and HK monoglucuronide (M2) in plasma, liver, kidney and brain following oral administration of HK (40 mg/kg) to healthy Wistar rats. The results showed that only HK but not M1 or M2 was found in brain.
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 이전글 |
Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats. |
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 다음글 |
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy. |
