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| A model of the ocular pharmacokinetics involved in the therapy of neovascular age-related macular degeneration with ranibizumab. | |||
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| 분류 | pharmacokinetics | 조회 | 1279 |
| 발행년도 | 2015 | 등록일 | 2015-09-24 |
| 출처 | Br J Ophthalmol (바로가기) | ||
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BACKGROUND:
To develop a model of the pharmacokinetics of vascular endothelial growth factor (VEGF-A) determined in samples of aqueous humour from patients with neovascular age-related macular degeneration (AMD) treated with ranibizumab (Lucentis).
METHODS:
Post hoc analysis of data from 31 eyes of 31 patients with AMD treated with ranibizumab gathered in a non-randomised, prospective clinical study. VEGF-A concentrations were measured in 440 aqueous humour samples by Luminex multiplex bead analysis (Luminex, Austin, Texas, USA).
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