Importance:

Obesity affects nearly one-sixth of US children and results in alterations to body composition and physiology that can affect drug disposition, possibly leading to therapeutic failure or toxic side effects. The depth of available literature regarding obesity's effect on drug safety, pharmacokinetics, and dosing in obese children is unknown.

Objective:

To perform a systematic literature review describing the current evidence of the effect of obesity on drug disposition in children.

 

(후략)