123I-iodobenzovesamicol (123I-IBVM) is a Single Photon Emission Computed Tomography (SPECT) selective radioligand for the vesicular acetylcholine transporter (VAChT), used to assess the integrity of cholinergic pathways in various neurological disorders. The current noninvasive method for quantitative analysis of 123I-IBVM, based on a reference tissue modeling (MRTM2), requires repeated scans for several hours, limiting its application in clinical trials. The objective is to validate a simplified acquisition method based on a single 123I-IBVM static scan preserving the quantification accuracy. Three acquisition times were tested comparatively to a kinetic analysis using MRTM2.

 

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