A two-period, crossover bioavailability study was conducted to evaluate the relative and absolute bioavailability of immediate (IR) and extended-release (XR) lamotrigine formulations under steady-state conditions in elderly patients with epilepsy. On treatment days, each subject's morning dose (IR or XR lamotrigine) was replaced with an intravenous 50 mg dose of stable-labeled lamotrigine.

 

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